10 Best Cradle Alternatives & Competitors (2026)

Insilico Medicine applies generative AI and deep learning across the full drug discovery pipeline, from target identification to clinical candidates. It focuses on small molecules and some biologics rather than peptide macrocycles. Versus Menten AI, Insilico provides end-to-end AI platforms with clinical-stage assets but does not emphasize physics-quantum hybrid optimization for oral macrocycles.

Exscientia uses AI-driven precision design to create small-molecule drugs, integrating patient tissue data and automated experimentation. Its approach centers on small molecules rather than peptide macrocycles. Relative to Menten AI, Exscientia offers broader therapeutic area coverage and automated labs but lacks Menten’s specific de novo macrocycle capabilities and reported nM potency metrics for PPIs.

Atomwise employs deep learning for structure-based small-molecule screening and design, primarily serving pharma partners. It does not specialize in generative peptide macrocycle design. Compared to Menten AI, Atomwise provides scalable virtual screening at lower cost but cannot match Menten’s physics-informed generative expansion of macrocycle chemical space.

BenevolentAI combines knowledge graphs and machine learning to generate drug hypotheses across modalities. Its platform is modality-agnostic rather than peptide-macrocycle specific. In comparison to Menten AI, BenevolentAI supports wider disease areas and data integration but lacks the targeted physics-quantum generative engine and >90% hit-rate claims for macrocycles.

Relay Therapeutics integrates computational and experimental methods focused on protein motion for small-molecule and some macrocycle programs. Its Dynamo platform emphasizes dynamic protein structures. Against Menten AI, Relay offers motion-based insights and internal pipeline assets but does not provide a standalone generative AI tool for de novo peptide macrocycles.

Cyclera focuses on computational design of cyclic peptides and macrocycles using specialized algorithms. It targets oral bioavailability challenges similar to Menten AI. However, Cyclera relies more on rule-based and physics-only methods without the integrated generative AI component that enables Menten’s de novo scale and reported cell-permeability results.

Peptilogics develops AI and computational platforms for peptide therapeutics, including macrocycle optimization. Its approach blends machine learning with experimental validation. Compared with Menten AI, Peptilogics offers broader peptide engineering services but does not highlight the same quantum-simulation hybrid or top-10 pharma partnership metrics for PPI targets.

Genedata supplies enterprise software for biopharma data analysis and screening workflows. It supports high-throughput peptide and biologic programs through data management rather than generative design. In contrast to Menten AI, Genedata excels at integrating existing experimental data but does not generate new macrocycle candidates from scratch with physics-AI hybrids.